Platelet-rich plasma in skin rejuvenation

Shahin Aghaei


Platelet-rich plasma (PRP) is a concentrate of platelet that has broadly been used to speed up the restoration of human skin tissues. Procedures of preparation would differ from method to method, depends on the concentration of various participating ingredients including proteins. 

Full Text:



Cervelli V, Palla L, Pascali M, De Angelis B, Curcio BC, et al. Autologous platelet-rich plasma mixed with purified fat graft in aesthetic plastic surgery. Aesth Plast Surg 2009; 33(5): 716–721. doi: 10.1007/s00266-009-9386-0.

Rivers KJ. Plasma-rich plasma: Should we wait for the verdicts? J Cut Med and Surg 2014; 18(3): 147–148.

Arshdeep, Kumaran MS. Platelet-rich plasma in dermatology: Boon or a bane? Indian J Dermatol Venereol Leprol 2014; 80(1): 5–14. doi: 10.4103/0378-6323.125467.

Cho JW, Kim SA, Lee KS. Platelet-rich plasma induces increased expression of G1 cell cycle regulators, type I collagen, and matrix metalloproteinase-1 in human skin fibroblasts. Int J Mol Med 2012; 29(1): 32–36. doi: 10.3892/ijmm.2011.803.

Kim DH, Je YJ, Kim CD, Lee YH, Seo YJ, et al. Can platelet-rich plasma be used for skin rejuvenation? Evaluation of effects of platelet-rich plasma on human dermal fibroblast. Ann Dermatol 2011; 23(4): 424–431. doi: 10.50 21/ad.2011.23.4.424.

Sclafani AP. Applications of platelet-rich fibrin matrix in facial plastic surgery. Facial Plast Surg 2009; 25(4): 270–276. doi: 10.1055/s-0029-1242033.

Sclafani AP. Platelet-rich fibrin matrix for improvement of deep nasolabial folds. J Cosmet Dermatol 2010; 9(1): 66–71. doi: 10.1111/j.1473-2165.2010.00486.x.

Ulusal BG. Platelet-rich plasma and hyaluronic acid—An efficient biostimulation method for face rejuvenation. J Cosmet Dermatol 2017; 16(1): 112–119. doi: 10.1111 /jocd.12271.

Redaelli A, Romano D, Marcianò A. Face and neck revi-talization with platelet-rich plasma (PRP): Clinical outcome in a series of 23 consecutively treated patients. J Drugs Dermatol 2010; 9(5): 466–472.

Elnehrawy NY, Ibrahim ZA, Eltoukhy AM, Nagy HM. Assessment of the efficacy and safety of single platelet-rich plasma injection on different types and grades of facial wrinkles. J Cosmet Dermatol 2017; 16(1): 103–111. doi: 10.1111/jocd.12258.

Min-Kyung S, Jong-Ho L, Sang-Jun L, Nack-In K. Plate-let-rich plasma combined with fractional laser therapy for skin rejuvenation. Dermatol Surg 2012; 38(4): 623–630 doi: 10.1111/j.1524-4725.2011.02280.x.

Lee JW, Kim BJ, Kim MN, Mun SK. The efficacy of autologous platelet rich plasma combined with ablative carbon dioxide fractional resurfacing for acne scars: A simultaneous split-face trial. Dermatol Surg 2011; 37(7): 931–938. doi: 10.1111/j.1524-4725.2011.01999.x.

Gawdat HI, Hegazy RA, Fawzy MM, Fathy M. Autolo-gous platelet rich plasma: Topical versus intradermal after fractional ablative carbon dioxide laser treatment of atrophic acne scars. Dermatol Surg 2014; 40(2): 152–161. doi: 10.1111/dsu.12392.

Abou Khedr NAE, Hussein TM, Abd El-Fatah AME. Comparing the role of subcision suction method with and without the injection of platelet-rich plasma in the treatment of depressed scars. J Surg Dermatol 2017; 2(2): doi: 10.18282/jsd.v2.i2.90. In Press.

Abuaf OK, Yildiz H, Baloglu H, Bilgili MR, Simsek HA, Dogan B. Histologic evidence of new collagen formulation using platelet rich plasma in skin rejuvenation: A prospective controlled clinical study. Ann Dermatol 2016; 28(6): 718–724. doi: 10.5021/ad.2016.28.6.718.

Uysal CA, Ertas NM. Does platelet-rich plasma therapy increase pigmentation? J Craniofac Surg 2016. In Press.

Kalyam K, Kavoussi SC, Ehrlich M, Teng CC, Chandha N, et al. Irreversible blindness following periocular autologous platelet-rich plasma skin rejuvenation treatment. Ophthal Plast Reconstr Surg 2016. In Press.


  • There are currently no refbacks.